Here is a complete tutorial (made with FotoSketcher 2.50) which will help you get started: FotoSketcher tutorial 1
And here is a more recent tutorial (made with FotoSketcher 3.30): FotoSketcher tutorial 2

If you are looking for advanced tips and tricks, check this post on the “FotoSketcher News” blog: FotoSketcher secrets

If you prefer, here is a quick video tutorial:

Here is a second and more advanced tutorial showing how to use multiple effects in FotoSketcher (best viewed in full screen):